Abnormal iron homeostasis and neurodegeneration

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Abnormal iron homeostasis and neurodegeneration

Abnormal iron metabolism is observed in many neurodegenerative diseases, however, only two have shown dysregulation of brain iron homeostasis as the primary cause of neurodegeneration. Herein, we review one of these - hereditary ferritinopathy (HF) or neuroferritinopathy, which is an autosomal dominant, adult onset degenerative disease caused by mutations in the ferritin light chain (FTL) gene....

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ژورنال

عنوان ژورنال: Frontiers in Aging Neuroscience

سال: 2013

ISSN: 1663-4365

DOI: 10.3389/fnagi.2013.00032